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Objective: The effects of evidence-based nursing care on quality of life and care satisfaction in patients with hypocalcemia after total thyroidectomy were assessed.Methods: A total of 62 patients who underwent total thyroidectomy were divided into two groups.Thirty patients were in the observation group and 32 were in the control group.Patients in the control group received routine nursing care where as those in the observation group received evidence-based nursing care.Quality-of-life scores and care satisfaction rates were compared between the two groups.Results: Quality-of-life scores and nursing care satisfaction rates were significantly higher in the observation group than the control group (P<0.05).Condusion: Evidence-based nursing had positive effects on the quality of life and nursing care satisfaction rate in patients with hypocalcemia after total thyroidectomy.