【摘 要】
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The canonical Wnt signaling pathway controls many developmental processes through a complex of β-catenin and the HMG-box transcription factors of TCF/LEF f
【机 构】
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Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Acade
【出 处】
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第六届海峡两岸生物医学和生物工程学术会议
论文部分内容阅读
The canonical Wnt signaling pathway controls many developmental processes through a complex of β-catenin and the HMG-box transcription factors of TCF/LEF family.In this study,we presented evidences to suggest that the T∶G mismatch-specific thymine-DNA glycosylase (TDG),an enzyme that functions in base excision repair of DNA damage,is a novel regulator of β-catenin-LEF-1 transcriptional complex.In a yeast two hybrid screening for proteins capable of binding to LEF-1,a member of TCF/LEF family,we isolated TDG.The interaction between TDG and LEF-1 was verified by co-immunoprecipitation experiment,testified to be direct in an in vitro pull-down assay,and colocalization of TDG with LEF-1 could be observed.
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