【摘 要】
：
Animals can generate both stereotypical and flexible motor sequences,but it remains largely unclear how the underlying neural circuit dynamics could seamlessly flow along different action trajectories
【机 构】
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University of science and technology of China,Hefei National Laboratory for Physical Sciences at the
【出 处】
：
第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis
论文部分内容阅读
Animals can generate both stereotypical and flexible motor sequences,but it remains largely unclear how the underlying neural circuit dynamics could seamlessly flow along different action trajectories.The behavioral repertoire of C.elegans comprises of three rudimentary components: moving forward,moving backward and doing turns,and the transitions between motor states over time give rise to motor sequences.Many neurons that are involved in different motor states have been identified,and we ask how they interact to generate flexible motor patterns.By employing systematic optogenetic manipulation,we found that activation or inhibition of different interneurons(e.g.,AIB and RIM)could trigger distinct motor sequences probabilistically,and the results are also dependent upon the duration of optogenetic stimulation.By examining neurotransmitter deficient mutants(e.g.eat-4)and postsynaptic receptor mutants(e.g.,avr-14,avr-15),we speculate that joint contributions from chemical synapses and gap junctions could modulate the transition probability between different motor states.
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