【摘 要】
：
Objective: Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain.However, few studies have systemically assessed the role of this signaling in direct nerve injury-induced
【机 构】
：
Department of Physiology & Neurobiology, Medical School of Zhengzhou University, 100 Science Avenue,
【出 处】
：
中华医学会疼痛学分会第十一届学术年会
论文部分内容阅读
Objective: Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain.However, few studies have systemically assessed the role of this signaling in direct nerve injury-induced neuropathic pain and the associated underlying mechanism.Methods: Rats received the spared nerve injury to induce neuropathic pain.The expressions of CXCL12/CXCR4, TNF-α and ERK in dorsal root ganglia (DRG) and spinal cord were detected by immunofluorescence staining and western blot.The pain-related behaviors were accessed by the up-down method to test paw withdrawal threshold.
其他文献
目的:慢性疼痛是伴发于各种抗原特异性的免疫相关疾病的常见症状,但其发生和发展病理机制尚不明确.既往研究表明,部分外周感觉神经元表达IgG的高亲和力受体FcγR Ⅰ,本研究致力于阐明IgG免疫复合物(IgG-IC)是否可以直接激活外周痛觉神经元而导致疼痛.方法:本研究采用在体和离体实验:在体实验中,大鼠足底皮内注射由抗原(卵清蛋白)和特异性IgG抗体合成的IgG-IC后检测痛觉相关行为;进一步利用背
目的:观察巴氯芬干预前后GABAA受体γ2亚基在坐骨神经压榨性损伤(Chronic Constriction Injury, CCI)模型大鼠背根神经节(Dorsal Root Ganglion,DRG)神经元上的表达.方法:制备CCI模型,热板实验检测热刺激缩足反射潜伏期(Thermal Withdrawal Latency, TWL);以灌胃的方式给予CCI模型鼠巴氯芬干预14天,取大鼠L4-
目的:分析慢性神经病理痛患者与对照者脑电功率谱的差异,探讨脑电功率谱分析在慢性神经痛患者中的应用价值.方法:收集就诊于北京大学人民医院及卫生部中日友好医院的带状疱疹后遗神经痛患者,入组条件:18～75岁,男女不限,无其他原因所致急慢性疼痛,无癫痫、老年痴呆、脑炎、脑外伤、脑血管病.另募集年龄性别与病例组匹配的对照者,无带状疱疹病史,余入组条件同病例组.所有观察对象均记录年龄、性别、病史、服药情况等
Objective: to evaluate the effect of chronic restraint stress in bee venom (BV) model.Methods: rats were subjected to 2 week restraint stress and paw withdrawal mechanical threshold (PWMT), paw withdr
Objective: Up-regulation of TRPV1 (transient receptor potential vanilloid subfamily, member 1)isassociated with the development and maintenance of cancer pain.The present study aims to investigate the
The International Association for the Study of Pain (IASP) was founded 40 years ago as a professional association of individual members dedicated to the study of the mechanisms of pain and to the trea
Objective: Bone cancer pain seriously affects the quality of life of cancer patients.Our previous study found that endogenous formaldehyde was produced by cancer cells metastasized into bone marrow an
Objective: During chronic pain states, peripheral nociceptivestimulation can induce long-term potentiation (LTP) inthe spinal dorsal horn, but it is not clear how quickly spinalLTP develops after peri
Objective: Neuropathic pain is a refractory disease characterized by maladaptive changes in gene transcription and translation in the sensory pathway.Long noncoding RNAs (lncRNAs) are emerging as new
Background: Studies showed that some chemotherapy drugs, such as oxaliplatin and paclitaxel et al, have not effect for the tumors of central nerve systemdue to the limited concentration of these BBB-p