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目的 hypoxia,aconditionoftenfoundinsolidtumors,Hypoxia-induciblefactor-1α(HIF-1α)isactivatedtoinducetargetgenesinvolvedininhibitionofapoptosis.Recently,nuclearfactor-κB(NF-κB)wasfoundtobeactivatedduringhypoxiaandregulatedtheexpressionofHIF-1.Therefore,wewanttoknowwhetherinhibitionofHIF-1byNF-κBcanenhancechemo-sensitivityduringhypoxiaconditions.