Evolutionary dynamics of intercellular signaling networks in human glioblastoma and anti-tumor thera

来源 :The 4th International Conference on Dynamics, Vibration and | 被引量 : 0次 | 上传用户:cxn0371
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Tumor cells do not develop in isolation, but co-evolve with stromal cells via an array of soluble mediators.Here we report a stochastic evolutionary population dynamics model to integrate prior biochemical data and construct a glioma microenvironment in silico, which comprises 5 types of cells, 15 cytokines, and 69 signaling pathways.
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