【摘 要】
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The genus Aconitum belongs to the family Ranunculaceae with over 300 species,widely distributed in the northern temperate zones and the mountainous regions of the subtropics,113 of which are Chinese e
【机 构】
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School of Life Science and Engineering, Southwest Jiaotong University Chengdu 610031, Sichuan, China
【出 处】
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中国化学会第十一届全国天然有机化学学术会议
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The genus Aconitum belongs to the family Ranunculaceae with over 300 species,widely distributed in the northern temperate zones and the mountainous regions of the subtropics,113 of which are Chinese endemic species 1.Aconitum species are plants with strong toxin due to the diterpenoid alkaloid contents.These alkaloids are neurotoxic agents,causing bradycardia,muscle-system spasms,hypotension and death by arrest of respiration.Aconitum preparations have been used in vary diluted forms as cardiotonics,febrifuges,sedatives,and anodynes.Now,Aconitum is very popular in homoeopathy and is included in many pharmaka 2-4.Aconitum apetalum is distributed in Xinjiang Uygur Autonomous region in China,and its chemical constituents were investigated for the first time.In the present study,from the root of this plant,twelve new C19-diterpenoid alkaloids,Apetaldines A-L (1-12) (Fig.1) were isolated,along with eight known alkaloids songorine,songomine,taurenine,cammaconine,acobretine E,8-O-ethylcammaconine,aconorine and deoxyaconitine by comparing spectroscopic data in the literature.Moreover,dimer anthranilic acid derivatives group was found in diterpenoid alkaloid for the first time.
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