原发性肝癌恶性程度高,起病隐匿,病情进展快,容易复发转移;而且我国肝癌多发生在肝炎、肝硬化基础之上,不仅造成机体的损伤,还降低肝脏的储备功能,严重影响肿瘤的治疗和预后.肝癌的治疗不仅需关注消除肿瘤本身,而且必须同时注重保护患者肝功能、减少肝功能损害.肝癌规范治疗的最主要评价标准是患者生存获益.
Background Clinical use of bioartificial liver (BAL) strongly relies on the development of human liver cell lines.The aim of this study was to establish and assess the potential usage of the HepG2 cel
Background & Aims The woodchuck model is an informative model for studies on hepadnaviral infection.In this study, woodchuck hepatitis virus (WHV) transgenic (Tg) mouse models based on C57BL/6 mice we
We have previously shown that polyinosinic-polycytidylic acid (poly (I ∶ C)) activates murine hepatic cells to produce interferon (IFN) and suppresses HBV replication in vitro.Therefore, we addressed
Background and ains Microvesicles (MVs) are membrane vesicles that are released from multiple cells.MVs contain proteins, lipids and nucleic acids of the original cells.The microRNAs (miRNAs) released
Objective To evaluate the effect of Fuzheng Huayu (FZHY) capsule on epithelial to mesenchymal transition (EMT) of hepatic stellate cells (HSCs) and EMT-based liver fibrosis.Methods Primary rat HSCs we
Objective Peroxisome proliferator-activated receptor gama (PPARgama) possesses general beneficial effects on non-alcoholic fatty liver disease, such as attenuating steatosis, inflammation and fibrogen
Objective To investigate the value of model for end-stage liver disease (MELD) score, MELD with incorporation of serum sodium (MELD-Na) score and integrated MELD (iMELD) score for evaluation of progno
Aims The long-term outcome of lamivudine therapy in HBeAg-positive chronic hepatitis B patients previously treated with IFN has rarely been reported.The aim of thhis study was to investigate the long-
Aim To evaluate the curative effect of partial splenic embolization in patients with portal hypertension and hypersplenism.Method In 100 patients the Seldinger techique was used to superselected embol