Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent mann

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：asjdkajsk

【摘要】

：

【作者】

：

Jia-jie GUO Guo-sheng WU Jiao-lin BAO Jin-jian LU Xiu-ping CHEN

【机构】

：

State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,U

【出处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

Cucurbitacin B ROS DNA damage G2/M arrest

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Aim: Cucurbitacin B (Cuc B), a natural triterpenoid with potent anti-cancer activities both in vitro and in vive, induces cancer cells cycle arrest at S or G2/M phases while the detailed mechanisms remain to be clear.This study was designed to precisely dissect mechamsms responsible for Cuc B-induced cell cycle arrest in human lung adenocarcinoma epithelial A549 cells.

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Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent mann

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