【摘 要】
：
Botulinum neurotoxins(BoNTs),produced by spore-forming anaerobic Clostridium botulinum,are the most toxic substances known.They cause the life-threatening d
【机 构】
：
Beijing Institute of Biotechnology,Beijing 100071
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Botulinum neurotoxins(BoNTs),produced by spore-forming anaerobic Clostridium botulinum,are the most toxic substances known.They cause the life-threatening disease botulism,characterized by flaccid muscle paralysis.While the natural cases of botulism are rare,due to their extreme toxicity and easy production,BoNTs have become potential biowarfare agents,and create maximum fear among populations concerned with bioterror agents.The only available antidote against BoNTs is equine antitoxin.Equine antitoxin can only target the toxins at extracellular level,and can not reverse the paralysis caused by botulism.In addition,equine antibody can cause severe hypersensitivity reactions,and is limited to be used for prophylaxis treatment[1].
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