Introduction: Dyshomeostasis of metal ions clearly occurs in AD brains.Previously,we reported SeP inhibited metal-induced aggregation and neurotoxicity of b
Protoporphyrinogen Oxidase(PPO)is the penultimate enzyme in the biosynthesis of chlorophyll and heme,catalyzes the conversion of protoporphyinogen Ⅸ to pro
A broad range of novel crosslinkers and probes have been designed and synthesized at Conju-Probe for chemical biology research,including PTAD,BCN,DBCO,tetra
Nucleic acid drug is challenging for their delivery efficiency,and cationic lipid is generally cytotoxic.In this paper,we described a novel cytimidine-based
The human Bloom syndrome gene(BLM)encodes a RecQ 3-5 DNA helicase,which is important in genomic stability by suppressing sister chromatid exchanges(SCE)duri
Although Waston-Crick base-pairing is central to DNA replication,the molecular basis of how DNA polymerases faithfully decode the chemical information on th
Our phenotypic screening of anti-cancer compounds in a library of multi-component reaction products found that a series of novel α-propiolamino-β-arylamin