【摘 要】
：
P21-activated kinase 4(PAK4),a serine/threonine protein kinase,was originally identified as an effector protein for Rho-family GTPases.1 PAK4 plays an impor
【机 构】
：
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education,Shenyang Pharma
论文部分内容阅读
P21-activated kinase 4(PAK4),a serine/threonine protein kinase,was originally identified as an effector protein for Rho-family GTPases.1 PAK4 plays an important role in regulating cytoskeletal organization,cell proliferation,migration,and nuclear signaling.2 In addition,PAK4 is over-expressed and amplified in a variety of human cancers and thus can be used therapeutically as an oncology target.Thus,identifying PAK4 inhibitors to treat cancer has attracted a great deal of attention in both academia and pharmaceutical industry.
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