【摘 要】
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Objective Attention-deficit/hyperactivity disorder (AD/HD),characterized by symptoms of inattention and hyperactivity-impulsivity,is a common neurodevelopmental disorder of childhood that often persis
【机 构】
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Addictive Substance Project,Tokyo Metropolitan Institute of Medical Science
【出 处】
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中华医学会第十一次全国精神医学学术会议暨第三届亚洲神经精神药理学术会议
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Objective Attention-deficit/hyperactivity disorder (AD/HD),characterized by symptoms of inattention and hyperactivity-impulsivity,is a common neurodevelopmental disorder of childhood that often persists into adult life.Since dopamine transporter (DAT)knockout (KO) mice show hyperactivity which can be treated with methylphenidate,DAT-KO mice are considered model mice for AD/HD.However,there have been few studies that focused on postnatal development of DAT-KO mice.We investigated association between postnatal development and methylphenidate induced inhibition of hyperactivity in DAT-KO mice.
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