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  5. A novel full-length Htt mouse model comprehensively recapitulates Huntington's disease patholog

A novel full-length Htt mouse model comprehensively recapitulates Huntington's disease patholog

来源 :The 6th FAONS Congress and 11th Biennial Conference of CNS(第 | 被引量 : 0次 | 上传用户：zjh73
【摘 要】
：
Many genetic mouse models of Huntingtons disease(HD)have been created but none fully recapitulate the cardinal phenotypes of HD.Transgenic mice expressing exon 1 of huntingtin show a severe phenotype
【作 者】
：
Sushuang Zheng Sushila A Shenoy Wencheng Liu Christopher A Ross Wenzhen Duan Chenjian Li 
【机 构】
：
School of Life Sciences,Peking University,Beijing,100871
【出 处】
：
The 6th FAONS Congress and 11th Biennial Conference of CNS(第
【发表日期】
：
2015年3期
【关键词】
：
Huntington’s disease (HD) mouse model BAC226Q 
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　　Many genetic mouse models of Huntingtons disease(HD)have been created but none fully recapitulate the cardinal phenotypes of HD.Transgenic mice expressing exon 1 of huntingtin show a severe phenotype but do not replicate the specific pattern of neuropathology characteristic of HD.
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