The physiological barriers of tumor itself are main challenges that blunt the non-surgical treatment of malignant solid tumors [1,2].The tumor extravascular barrier(TEVB)composed of tumor extracellular matrix(ECM)and multiple layers of tumor cells(MLTC)is the most formidable one [3].Based on this consideration,we reported herein a core-shell and size multistage changeable nanocarrier that could overcome the double barriers from ECM and MLTC.