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Background: Black angiotensiongen (POMC), which is present in the adenohypophysis of macromolecular substances, the main derived peptide is beta-endorphin (β-EP) and adrenocorticotropic hormone (ACTH).ACTH and β-EP are the important neural peptides which composed of the neuroendocrine network systems, involved in function of the regulation of body temperature, respiratory function, cardiovascular function and immune regulation function and associated with memory.