Objective To investigate the association of single nucleotide polymorphism (SNPs) of interleukin-6 (IL-6) and C-reactive protein (CRP) with hypertension induced by obstructive sleep apnea syndrome (OSA).Methods A total of 300 male patients diagnosed as severe OSA, with 145 patients diagnosed as hypertension, were enrolled in this study.One hundrerd randomly selected healthy males were served as normal controls.The SNPs of rs1800796 and rs1800795 in the promoter region of IL-6, and rs3091244 and rs1205 in CRP were genotyped in OSA patients with or without hypertension, and health individuals.The contribution of IL-6 and CRP Polymorphisms to hypertension in the patients of OSA was evaluated.Results The frequency of the rs1800796 GG genotype in OSA with hypertension was significantly higher than those without hypertension (11.0% vs.4.1%).So was the frequency of the CG genotype of IL-6 rs1800795 (6.2% vs.0.6% respectively).The frequency of the C allele of IL-6 rs1800795 in OSA with hypertension was also higher than those without (3.1% vs 0.3% respectively).The frequency of CT genotype in CRP rs3091244 was significantly higher in the OSA patients with hypertension than those without (17% vs 7%), so was the frequency of T allele in rs3091244 (9% vs.3%).The frequency of CC genotype in CRP rs1205 was also higher in the OSA patients with hypertension than those without (25% vs 11%).Conclusion IL-6 and CRP SNPs is associated with hypertension in the OSA patients.