【摘 要】
:
Potassium inward rectifying (Kir) channels are a class of transmembrane proteins which play important roles in various physiological processes, controlling the resting membrane potential, regulating e
【机 构】
:
Institute of Biophysics, Hebei University of Technology, Tianjin, China
【出 处】
:
The 4th International Ion Channel Conference(第四届国际离子通道会议)
论文部分内容阅读
Potassium inward rectifying (Kir) channels are a class of transmembrane proteins which play important roles in various physiological processes, controlling the resting membrane potential, regulating excitability of cardiac cells and neurons, coupling insulin secretion and maintaining electrolyte balance.Kir channels prefer to conduct inward currents at membrane voltages negative to the K+ equilibrium potential other than outward currents at voltages positive to it, even with equal K+ concentrations on both sides of the membrane.This conduction property, named as inward rectification,is not an inherent property of the channel protein itself, but reflects strong voltage dependence of channel block by intracellular cations such as Mg2+ and polyamines.
其他文献
Among all sensory organs in mammals, those that sense light touch are the least understood mechanistically.Friedrich Merkel proposed 138 years ago that Merkel cells are mammalian tactile-transducers b
Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation.Clinically, retinoids are effective in treating many sk
Purinergic signaling contributes significantly to cutaneous, musculoskeletal and visceral nociception and on the roles played by P2X3, P2X2/3, P2X4, P2X7 ATP receptor channels in neuropathic and infla
M-type K+ channels, encoded by the KCNQ2-5 family of genes, play key roles in the regulation of neuronal excitability.We study the regulation of M-channel activity and transcriptional expression by A-
Transient receptor potential (TRP) channels are polymodal cation channels that provide one of the main pathways for cation influx in excitable and non-excitable cells.Among them, the six thermo-sensit
Phosphoinositides are a family of phospholipids in the cytoplasmic leaflet of plasma membranes and cell organelles.They are minority lipids differing by the degree of phosphorylation of the inositol h
Neutrophils are the first line of host defense against invading microorganism or other inflammatory stimuli in the innate immune system, and contribute to inflammation-related tissue injuries, associa
Kv1.3 channels have become a novel target for the treatment of autoimmune diseases.Searching for specific Kv1.3 potassium channel inhibitors has become the current hot spot for the treatment of autoim
Inward rectifier potassium (Kir) channels regulate cell resting membrane potential andexcitability.Like many other types of ion channels, the activity of Kir channels transport K+ ions cross membranes
Necrosis is an important form of cell demise during organ development and diseases.Traditionally, necrosis has been considered as an accidental, uncontrolled form of cell death.Increasing evidence now