骨架蛋白p62结合对蛋白激酶Cξ活力影响的酶动力学研究

来源 :第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会 | 被引量 : 0次 | 上传用户：puppy_tang

【摘要】

：

　　蛋白激酶Cζ(PKCξ)是蛋白激酶C家族的成员之一,属于非典型PKC(aPKC)的一种.有报道指出PKCξ能够利用其N端PB1结构域和骨架蛋白p62结合,并参与调控NF-κB信号通路.PKCξ

【作者】

：

任鋆吴嘉炜王志新

【机构】

：

清华大学生命科学学院,北京100084

【出处】

：

第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会

【发表日期】

：

2013年5期

【关键词】

：

蛋白激酶Cξ p62 酶动力学研究

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论文部分内容阅读

　　蛋白激酶Cζ(PKCξ)是蛋白激酶C家族的成员之一,属于非典型PKC(aPKC)的一种.有报道指出PKCξ能够利用其N端PB1结构域和骨架蛋白p62结合,并参与调控NF-κB信号通路.PKCξ序列中含有一段假底物区,可以使激酶在缺失上游激活信号时处于非活性的状态.由于其序列特殊性,aPKC并不受钙离子、二脂酰甘油等第二信使的调控,人们推测可能主要依靠结合蛋白的相互作用来完成活力的改变.

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骨架蛋白p62结合对蛋白激酶Cξ活力影响的酶动力学研究

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