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Objective: We had previously demonstrated that the carbohydrate antigen 19-9(CA19-9),lactate dehydrogenase(LDH),neutrophil lymphocyte ratio(NLR)are prognostic factors for patients with metastatic colorectal cancer(mCRC).In this study,we try to analysis the association of these blood-based biomarkers with bevacizumab efficacy in the first line setting.