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  5. In vivo study of the potential activity of inducing apoptosis of Lentinan

In vivo study of the potential activity of inducing apoptosis of Lentinan

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：wnt
【摘 要】
：
In this study, a purified polysaccharide was extracted and isolated from the fruitbodies of Lentinus edodes, and its anti-tumour effect and apoptosis-inducing activity in S 180 tumour bearing mice has
【作 者】
：
Qiang Li Kai-ping Wang Yu Zhang 
【机 构】
：
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, No.1277,Jie
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
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In this study, a purified polysaccharide was extracted and isolated from the fruitbodies of Lentinus edodes, and its anti-tumour effect and apoptosis-inducing activity in S 180 tumour bearing mice has been investigated.Results showed that JLNT enhanced the Bax/Bcl-2 ratios by up-regulating Bax and down-regulating Bcl-2, leading to the activation of caspase-3 and finally the initiation of cell apoptosis in S 180 tumour bearing mice(Fig.1).
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