【摘 要】
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Breast cancer has a high incidence rate in the world and is becoming a leading cause of death in female pa tients due to its high metastatic ability.High expression of Notch-1 and Jagged-1,the ligand
【机 构】
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Department of Biophysics,School of Life Science and Technology,University of Electronic Science and
【出 处】
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第十一届全国生物力学学术会议暨第十三届全国生物流变学学术会议
论文部分内容阅读
Breast cancer has a high incidence rate in the world and is becoming a leading cause of death in female pa tients due to its high metastatic ability.High expression of Notch-1 and Jagged-1,the ligand of Notch-1,corre lates with poor prognosis in breast cancer.Our previous work has shown that the activation of Notch-1 leads to NF-κB activation by inducing the nuclear translocation of p65,a subunit of NF-κB,and consequently upregu lates NF-κB transcriptional activation and induce the adhesion,migration,and invasion of human breast carci noma MDA-MB-231 cells.The aim of the present study is to elucidate how Notch-1 regulates NF-κB activation to induce the migration and invasion of breast cancer cells.
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