OBJECTIVE: This study aimed to investigate the influence of different anesthetic methods on serum high sensitivity C-reactive protein (hs-CRP) in aged hypertensive patients undergoing joint replacement for lower extremity.METHODS: Thirty consecutive aged patients (ASAⅡ-Ⅲ) with hypertension undergoing scheduled total knee or hip replacement were enrolled in this study.The patients were randomly divided into general anesthesia group (group A) and subarachnoid block group (group B).The hemodynamics was monitored continuously during operation, and the serum level of hs-CRP was examined before anesthesia induction (T0), 5 min (T1) after anesthesia induction, 1 h (T2) after surgical incision, and at the end of operation (T3).One-way ANOVA analysis was used to investigate the difference in the level of hs-CRP between the time points.