【摘 要】
：
Aims Our study aimed to investigate the protective effects of Holothurian intestines (HI) on nonsteroidal anti-inflammatory drugs (NSAIDs) induced gastric mucosal damage in rats.Materials and methods
【机 构】
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Department of Infectious Diseases, Affiliated Hospital of Qingdao University
【出 处】
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The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
论文部分内容阅读
Aims Our study aimed to investigate the protective effects of Holothurian intestines (HI) on nonsteroidal anti-inflammatory drugs (NSAIDs) induced gastric mucosal damage in rats.Materials and methods Gastric lesions on 60 male wistar rats were induced with indomethacin (IDM, 30mg/kg).The rats were pretreated for 15 consecutive days with saline, sucralfate, and HI in different doses (0.4 g/kg, 0.8 g/kg and 1.6 g/kg, respectively).Fasting for 24 h, the animals were administered with IDM; after 6 hours,killed.
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