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In recent year,Enterovirus 71 (EV71)-associated hand foot and mouth disease(HFMD) has become an important public health issue in China.EV71 has been classified into genotypes A,B1-B5 and C1-C5.With such genetic diversity ,whether the convalescent or recovery antibody responses can cross-protect infections from other genotypes remains a question.Understanding of the antigenicity of such diverse genetic EV71 isolates is crucial for the EV71 vaccine development.