Objectives Cervical carcinoma is likely to become one of the most important indications for laparoscopic radical surgery.The laparoscopic technique combines the benefits of minimal invasive approach with established surgical principles.In our institution the laparoscopic radical hysterectomy and trans-peritoneal ap proach lymphadenectomy have become the standard techniques for invasive cervical cancer.We report the indi cations, techniques, results and oncological outcome in a single center experience.Methods Between February 2001 and June 2007 we performed laparoscopic radical hysterectomies for cervical cancer in 295 patients.Their initial techniques, operation data, complications, post-operative course, oncological outcome and survival were evaluated.Results 290 procedures out of 295 were successful.Para-aortic lymphadenectomy was performed in 156 (52.9%) patients and pelvic lymphadenectomy was performed in all 295 patients.The median blood loss was 230 ml (range 50-1200 ml).The mean operation time was 162 min (range 110-350) which included the learning curves of three surgeons.In five cases (1.7%) conversion to open surgery was necessary due to bleeding (3 cases), bowel injury (1 case) and hypercapnia (1 case).Other major intra-operative injuries occurred in 12 (4.1%) of the patients.Positive lymph nodes were detected in 80 cases (27.1%), lymphovas cular space invasion in 54 cases (18.3%) and surgical margins were negative for tumor in all patients.The mean hospital stay was 10.3 days.Post-operative complications occurred in 10.8% patients, uretero-vaginal fistula in 5 cases, vesico-vaginal fistula in 4, uretero-stenosis in 3 cases, deep venous thrombosis in 9 cases, lymphocyst in 4 cases, lymphedema in 5 cases 1 case with trocar insertion site metastasis.Other medical prob lems included 47 (15.9%) cases of bladder dysfunction and 62 (21.0%) cases of rectum dysfunction or consti pation.The median follow-up was 36.45 months (range 8-76 months).48 (16.3%) patients had recur rences or metastasis.Of these patients, 43 (14.6) have died of their disease and 5 (1.7%) are alive with dis ease.The overall disease-free survival was 95.2% for Ⅰa, 96.2% for Ⅰb, and 84.5% for Ⅱa, 79.4% for Ⅱb, 66.7% for Ⅲa and 60.0% for Ⅲb respectively.Conclusions Laparoscopic radical hysterectomy is a routine, effective treatment for patients with Ⅰa2-Ⅱb cervical carcinoma.With more experience it is envisaged that Ⅱb stage patients can be managed safely offering all the benefits of minimal surgery to the patients.Although no long -term follow-up is available our follow-up data for up to 76 months confirm the effectiveness of laparoscopic radical hysterectomy in terms of surgical principles and oncological outcome.