Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户:zhangwenda_gz
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  DNA 5-hydroxylmethylcytosine(5hmC)catalyzed by ten-eleven translocation methylcytosine dioxygenase(TET)occurs abundantly in neurons of mammals.However,the in vivo causal link between TET dysregulation and nociceptive modulation has not been established.Here,we found that spinal TET1 and TET3 were significantly increased in the model of formalin-induced acute inflammatory pain,which was accompanied with the augment of genome-wide 5hmC content in spinal cord.
其他文献
Background: Progress has been made in the treatment of cancer leading to a sharp increase in the number of survivors.However,cancer treatment poses severe side effects including the consequences of ne
会议
Recent studies indicate that innate host immune responses play critical roles in the pathogenesis and progression of vascular disease.However,the molecular processes that initiate and propagate the in
会议
Objective: T-helper(Th)17 cells are a new member in CD4+T lymphocytes and have a strong proinflammatory property.Neuroinflammation mediated by glial cells has been presented as a novel pathogenesis of
Introduction: Epidemiological studies have shown that the incidence of atrial fibrillation(AF),the most common type of arrthymia,is more than doubled in cancer patients than in general population,and
会议
会议
会议
Since President Obama announced the "Precision Medicine Initiative",precision medicine has been played more and more attention.However,clinicians have already used it to treat conditions like cancer a
会议
Chronic visceral pain is a multifaceted and complex condition,which is poorly managed by current available drugs.The persistent nature of pain indicates that epigenetic machinery may be a crucial fact
会议
会议
Neuropathic pain,a distressing clinical condition,is hard to treat in part due to incompletely understanding nerve injury-induced changes in gene transcription and translation in first-order sensory n
会议