Self-assembly of RNF126 into inactive homodimers releases functionally active forms of RNF8 in respo

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：zhouyiai1015

【摘要】

：

【作者】

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Yoojeong Seo Nam Soo Lee Sumi Kim Sunyoung Park Hongtae Kim Yonghwan Kim

【机构】

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Department of Life Systems,Sookmyung Women's University,Seoul 140-742,Republic of Korea

【出处】

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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

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2015年3期

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Cells have evolved sophisticated mechanisms to maintain genomic integrity in response to DNA damage.As important as is activation of DNA damage signaling cascades, negative regulation of DNA damage response (DDR) is also crucial for preventing unintended cellular consequences.Here, we identified RNF 126 as a novel negative regulator of the DDR.

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