【摘 要】
：
Pulmonary sustained delivery is becoming a novel drug delivery system which has attracted much attention in recent years.LPPs (Large Porous Particles, LPPs) with the diameter larger than 5 μm, the den
【机 构】
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Clinical Undergraduates of Class 18 Grade 2011,Basic College of Weifang Medical University,Weifang 2
【出 处】
：
2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
Pulmonary sustained delivery is becoming a novel drug delivery system which has attracted much attention in recent years.LPPs (Large Porous Particles, LPPs) with the diameter larger than 5 μm, the density less than 0.4 g/cm3 are considered to have more advantages for pulmonary drug delivery systems.In this study, inhalable LPPs were designed to reduce side effects, provide drug protection and to sustained release Quaternized Chitosan (HTCC) and Hydroxypropyl-β-cyclodextrin (Hp-β-CD) were applied to develop large porous microspheres for pulmonary delivery by spray drying method, while the cyclosporine A (CsA) was used as a model drug.The physiochemical characteristics such as morphology, drug loading, and encapsulation efficiency were evaluated.
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