Molecular Modeling of Interplay between Nanoparticle Wrapping and Clustering of Inner Anchored Membr

来源 :中国化学会生物物理化学专业委员会第四届全国生物物理化学会议 | 被引量 : 0次 | 上传用户:xuruiqi8627361
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The receptor mediated endocytosis of nanoparticles(NPs)is known to be size and shape dependent but regulated by membrane properties,like tension,rigidity and especially membrane proteins.Compared with transmembrane receptors which directly bind ligands to provide the driving force for passive endocytosis,the hidden role of inner anchored membrane proteins(IAMPs),however,has been grossly neglected.Here,by applying the N-varied dissipative particle dynamics(DPD)techniques,we present the first simulation study on the interplay between wrapping of NPs and clustering of IAMPs.
其他文献
  化疗耐药常发生于癌症病人治疗期间,导致许多肿瘤常规化疗效果差,预后不良等困扰临床的重要难题。起初大部分患者化疗治疗方法有反应,肿瘤缩小或是病情稳定。然而,耐药在6-12
  Alzheimer's disease(AD)is associated with the aggregation of the amyloid-beta(Aβ)peptides into toxic aggregates.How to inhibit the aggregation of Aβ pepti
会议
  The first step in most viral infections is the penetration of the cell membrane via endocytosis.However,the underlying mechanism of this important process h
会议
  多态性蛋白Mad2 折叠与功能的研究摘要:Mad2 是纺锤体检查点(Spindle Assembly Checkpoint,SAC)的关键蛋白,在有丝分裂过程中能阻止未成熟的姐妹染色单体分离以确保遗传物
  多巴胺是脑内一种重要的神经递质,通过不同亚型多巴胺受体调控生命体运动功能、认知活动、情感等生理或病理过程,与帕金森病(Parkinson’s disease,PD)的病理机制与防治
  Nucleotides are essential components of DNA and RNA,and their functions depend mainly on the participation of metal ions.Thus,research into nucleotide-metal
会议
  Proteins with low sequence identity but comparable tertiary structure and functions have been valuable to uncover the relationship between sequence,tertiary
会议
  The development of fluorescent tools with high fluorescence quality and efficient targeting is of great importance in immunoassay.Here we report combination
会议
  Single-walled carbon nanotubes(SWCNTs)are widely used in different areas especially the field of biomedicine as drug vehicles.However,large scale production
会议
  Circadian clocks are intrinsic,time-tracking systems that enable organisms to anticipate environmental changes and allow them to adapt their behavior and ph
会议