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  5. Targeting cPLA2 inhibition to reduce lysophosphatidylcholine (LPC) production induced by Cdk5/p25: A

Targeting cPLA2 inhibition to reduce lysophosphatidylcholine (LPC) production induced by Cdk5/p25: A

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：hanosn
【摘 要】
：
Aim: The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 and neuroinflammation has been linked to the pathogenesis in a number of neurodegenerative diseases such as Alzheimers disease (AD), AL
【作 者】
：
Chian-Ming LOW Shi-Yu CHAN Jeyapriya R SUNDARAM Sashi KESAVAPANY 
【机 构】
：
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 28 Me
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
neuroinflammation Cdk5/p25 cytosolic phospholipase A2 lysophosphatidylcholine as 
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Aim: The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 and neuroinflammation has been linked to the pathogenesis in a number of neurodegenerative diseases such as Alzheimers disease (AD), ALS and PD.In this report, we aim to delineate the precise mechanism behind the induction of neuroinflammation and its significance in the AD pathogenesis.
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