Here we report a novel and simple method for fabrication of monodisperse hollow microcapsules with stimuli-responsive membranes in microfluidic devices.First,we prepared a novel type of monodisperse thermo-induced self-bursting microcapsules with magnetic-targeting property (Figure 1) through microfluidics approach.Oil-in-water-in-oil (O/W/O) double emulsions generated by microfluidic device were used as templates to prepare these core/shell microcapsules.Each of the microcapsule comprises an oil core and a thermo-responsive shell composed of poly(N-isopropylacrylamide) (PNIPAM) and homogeneously embedded superparamagnetic Fe3O4 nanoparticles.The oil core in the microcapsule can be used to encapsulate lipophilic drug molecules.In the shell,the embedded Fe3O4 nanoparticles contribute superparamagnetic property to the microcapsule and the PNIPAM network makes the shell thermo-responsive.The microcapsules can be transported to a desired site under magnetic guide,and subsequently burst release their encapsulated lipophilic substances via an external thermal trigger.Compared with the currently-existed microcapsules with hydrophilic core,our microcapsules enables not only magnetic-guided targeting,but also the encapsulation of lipophilic chemicals,no leakage at all before thermo-triggering,and rapid and complete release after thermo-induced self-bursting.Besides the application in the field of targeted delivery and controlled release of drugs,these multifunctional microcapsules can fimd myriad applications in various fields.Since the lower critical solution temperature of PNIPAM-based polymeric shell can be precisely adjusted,and the thermo-responsive shells can be easily converted into other stimuli-responsive ones such as pH-responsive,molecular-recognizable,and glucose-responsive,we therefore believe that,this research will show importance in the design and fabrication of multifunctional microcapsules.