The Rapeutic Role of Soluble IL-17RC on Inflammation and Bone Destruction in Collagen-Induced Arthri

来源 :首都医科大学第三届研究生学术论坛 | 被引量 : 0次 | 上传用户：CoolTNTmax

【摘要】

：

【作者】

：

Yuxuan Du Huihui Yuan Wenming Zhao

【机构】

：

Department of Immunology, School of Basic Medical Sciences, Capital Medical University,No.10 Xitouti

【出处】

：

首都医科大学第三届研究生学术论坛

【发表日期】

：

2015年9期

【关键词】

：

Soluble IL-17RC Inflammation bone destruction Collagen-induced arthritis (CIA)

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objectives To engineer a dual functional soluble IL-17RC to ameliorate symptoms of inflammation and bone destruction in collagen-induced arthritis mice by neutralizing IL-17A and IL-17F.Methods The standard molecular biological techniques were used to engineer soluble IL-17RC, and binding, affinity and neutralization were examined by ELISA.

其他文献

CXCR4/CXCL12 Axis Promotes VEGF-Mediated Colorectal Cancer Angiogenesis Through PI3K/Akt and MEK/ERK

Chemokine CXCL12 is an extracellular chemokine which binds to its cell surface receptor CXCR4.High expressions of CXCR4 and CXCL12 are associated with biological malignant potential in colon cancers.H

会议

Colon cancerthe CXCR4/CXCL12 axisHuman vascular endothelial cellAngiogenesis

Simultaneous Determination of the Six Active Ingredients of Rhodiola by UPLC-MS / MS Method and the

Rhodiola is a popular plant in traditional medical systems in Eastern Europe and Asia with a reputation for stimulating the nervous system, decreasing depression, enhancing work performance, eliminati

会议

RhodiolaUPLC-MS/MShypoxiaactive ingredients

Selection of Genes Associated with Variations in the Circle of Willis in Gerbils Using Suppression S

Deformities in the Circle of Willis (CoW) can significantly increase the risk of cerebrovascular disease in humans.However, the molecular mechanisms underlying these deformities have not been understo

会议

Suppression subtractive hybridizationGerbilsthe Circle of WillisCST3GNASGPx

Microsatellite Instability Detected in Tumor-Related Genes in C57BL/6J Mice with Thymic Lymphoma Ind

Microsatellite instability (MSI) has been observed within tumors and found to be closely associated with the degree of malignancy and prognosis in tumors.However, whether MSI in tumor-related genes ca

会议

N-methyl-N-nitrosourea (MNU)microsatellite instability (MSI)thymic lymphomaC5

Independent Tumor Origins in Synchronous Bilateral Clear Cell Renal Cell Carcinoma

Background: Most renal cell carcinoma (RCC) occur in one kidney;however, in a small set of patients (0.7-4.7%), RCCs occur in both kidneys (bilateral RCC).This particular type of RCC poses a challenge

会议

clear cell renal cell carcinomabilateraltumorigenesiswhole exome sequencing

Characteristics of a Newly Established Diabetic Gerbil Group and Expression Analysis of Diabetes Rel

Diabetes is a global public health problem and about 90% of which is type 2 diabetes mellitus (T2DM).To better understand the pathogenesis and potential therapeutic target, the animal models of T2DM a

会议

diabetic animal modelMongolian gerbilleptinadiponectin

Up-Regulation of Urotensin Ⅱ and Its Receptor Contributes to Human Hepatocellular Carcinoma Growth v

Urotensin Ⅱ (UⅡ) and its receptor (UTR) have mitogenic effects on tumor growth.Our previous study demonstrated that the UⅡ/UTR system is up-regulated in dithyinitrosamineinduced precancerous rat liver

会议

urotensin Ⅱhuman hepatocellular carcinomacell proliferationsignaling pathway

The Persistent Deleterious Effects of High Angiotensin Ⅱ on Hypertension and Vascular Injury via Act

Backgroud: Activation of the rennin-angiotensin system plays a critical role in the development of hypertension and its complication.Our previous study has demonstrated that a cellular "memory" is inv

会议

Angiotensin ⅡHypertensionNADPH oxidasesFree radicals

β1肾上腺素受体自身抗体可促进调节性T淋巴细胞(Tregs)活化但其高滴度存在可削减Tregs对心肌细胞的保护作用

目的：T淋巴细胞紊乱和自身抗体的存在是心衰恶化的重要免疫学机制,β1肾上腺素受体自身抗体(β1AA)在心衰患者血清中呈高阳性率、高滴度分布,用免疫吸附法将其去除后,患者的心功能明显改善、同时调节性T淋巴细胞(Treg cells)的数目也显著增多.CD4+CD25+nTreg cells的数量和功能与患者的心功能正相关,其异常也是CD4+T cells亚群失衡及自身抗体产生的重要因素.β1AA可诱

会议

β1肾上腺素受体自身抗体(β1AA)Treg cells心肌细胞

Anti-peroxynitrite Treatment Ameliorate Vasorelaxation of Resistance Arteries in Aging Rats:Involvem

Numerous studies have found that age-associated structural and functional alterations in arteries were characterized by increased endothelial dysfunction both in human and animal studies.

会议

PeroxynitriteVasorelaxationResistance ArteriesAgingCirculating Endothelial P

The Rapeutic Role of Soluble IL-17RC on Inflammation and Bone Destruction in Collagen-Induced Arthri

与本文相关的学术论文