【摘 要】
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Objective Epidemiological studies have demonstrated that ABO blood groups were associated with several chronic inflammation related diseases,including cancers and cardiocerebrovascluar diseases.Howeve
【机 构】
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TIANJIN MEDICAL UNIVERSITY CANCER INSTITUDE & HOSPITAL
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Objective Epidemiological studies have demonstrated that ABO blood groups were associated with several chronic inflammation related diseases,including cancers and cardiocerebrovascluar diseases.However,the relationship between histoblood group antigens and inflammation related diseases remains unknown and the regulatory mechanisms underlying ABO expression was still unclear.Several SNPs in the ABO gene have been suggested to be associated with increased risks to the development of cancer and cardiocerebrovascluar disease by genome-wide association studies(GWAS)and candidate gene studies.However,several new findings of ABO gene SNPs have been reported in recent years and the relationship between SNPs in ABO gene and overall cancer/cardiocerebrovascular diseases risk still unclear.In this study,we conducted a systematic review and meta-analysis to clarify the association between two SNPs(rs505922 and rs657152)in ABO gene and cancers/cardiocerebrovascular diseases.
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