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  5. Depletion of PINK1 sensitizes breast cancer cells to polyphyllin Ⅰ via mitophagy suppression and DRP

Depletion of PINK1 sensitizes breast cancer cells to polyphyllin Ⅰ via mitophagy suppression and DRP

来源 :中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛 | 被引量 : 0次 | 上传用户：gaolch011
【摘 要】
：
OBJECTIVE To elucidate the molecular mechanism and the anti-breast cancer effect of polyphyllin Ⅰ ,which is a natural compound extracted from Rhizoma of Paris polyphyllin.METHODS Human breast cancer c
【作 者】
：
LI Guo-bing FU Ruo-qiu SHEN Han-ming ZHOU Jing HU Xiao-ye LIU Yan-xia LI Yu-nong ZHANG Hong-wei LIU Xin ZHANG Yan-hao HUANG Cheng ZHANG Rong GAO Ning 
【机 构】
：
College of Pharmacy, 3rd Military Medical University, Chongqing 400038, China;Department of Pharmacy
【出 处】
：
中国药理学会第十四次全国学术大会暨施维雅优秀青年药理学工作者奖20周年学术论坛
【发表日期】
：
2016年11期
【关键词】
：
polyphyllin Ⅰ PINK1 mitophagy DRP1 mitochondrial fission apoptosis 
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　　OBJECTIVE To elucidate the molecular mechanism and the anti-breast cancer effect of polyphyllin Ⅰ ,which is a natural compound extracted from Rhizoma of Paris polyphyllin.METHODS Human breast cancer cells were treated with polyphyllin Ⅰ , after which DRP1-dependent mitochondrial fission and apoptosis, mitophagy and PINK1/PARK2 pathway were evaluated.
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