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  5. The Absence of Dystrophin Rather Than Muscle Degeneration Causes Acetylcholine Receptor Cluster Defe

The Absence of Dystrophin Rather Than Muscle Degeneration Causes Acetylcholine Receptor Cluster Defe

来源 :The 12th Annual Asian and Oceanian Myology Center (AOMC)Scie | 被引量 : 0次 | 上传用户：xiaoc009
【摘 要】
：
Objective To explore whether the disruption of AChR distribution in mdx mice is due to lack of dystrophin or whether it is downstream of muscle degeneration.Method AChR clusters and muscle degeneratio
【作 者】
：
jie Kong liqing Yang qiuling Li jiqing Cao juan Yang fei Chen yanyun Wang cheng Zhang 
【机 构】
：
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhong Shaner Road
【出 处】
：
The 12th Annual Asian and Oceanian Myology Center (AOMC)Scie
【发表日期】
：
2013年7期
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Objective To explore whether the disruption of AChR distribution in mdx mice is due to lack of dystrophin or whether it is downstream of muscle degeneration.Method AChR clusters and muscle degeneration were compared between mdx mice (mutated dystrophin) and dko mice (mutated dystrophin and utrophin).AChR clusters were identified by binding with a-bungarotoxin, and pathological features were observed by classical immunohistochemical techniques.
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