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Osteoporotic vertebral compressed fractures (VCFs) are the most common osteoporotic fractures.Although percutaneous vertebroplasty (PVP) reportedly relieves pain and improves function,a recent pooled analysis from two multicenter randomized controlled trials concluded the improvement in pain and disability treated with PVP was similar to those with sham surgery.Using meta-analysis we therefore asked whether compared with either nonoperative therapy or a sham injection for patients with VCF,PVP would (1) better relieve pain,(2) provide greater improvement in pain-related disability,and (3) increase the recurrence of vertebral fractures.We searched PubMed,EMBASE,Medline,and the Cochrane library using the keywords "vertebroplasty AND osteoporosis OR fracture".