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目的 Toestablishareliablebrainmetastaticmodelfromlungcancer.方法 Four-week-oldmicewererandomlydividedinto4groups,receivingPC-9orA549lungcancercellsviatail-veininjectionorleftventricularinjection.ChangesofvitalsignsofthenudemicewerecarefullyobservedandabnormalsignswereexaminedbyMRIandSPET/CTimaging.TherateoforganmetastasisandthenumberofmetastaticorganswereanalyzedbypathologicalexaminationandHEstaining.