【摘 要】
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This work determined the mechanisms of enhancing the oral bioavailability of syringaresinol (SG).The in situ perfusion method was used in rats to study the
【机 构】
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Department of Pharmacy,Beijing University of Chinese Medicine,Beijing,CHINA
【出 处】
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2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
This work determined the mechanisms of enhancing the oral bioavailability of syringaresinol (SG).The in situ perfusion method was used in rats to study the absorption mechanisms of SG alone or combined with the P-gp inhibitors Verapamil (Ver).The absorption of syringaresinol decreased followed the sequence of duodenum, jejunum, ileum.The absorption in ileum was obviously lower than those in other intestinal segments (P<0.05).Compared with SG group, SG +Ver was increased significantly(P<0.05), Ver remarkably enhanced the effect of intestinal absorption of SG on duodenum(P<0.05), The results of absorption in the intestines indicated that Efflux pump P-gp might exert some effects on the absorption of SG.In conclusion, these data indicate that P-gp inhibitors are an effective and promising delivery system to enhance the oral bioavailability of poorly water-soluble drugs.
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