【摘 要】
：
Citalopram,chemically 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroiso-benzofuran-5-carbonitrile,is a serotonin reuptake inhibitor(SSRI).The pharmacological activity lies predominantly in i
【机 构】
：
Department of Chemical Engineering,I-Shou University,Kaohsiung,Taiwan,ROC
【出 处】
：
43rd International Symposium on High Performance Liquid Phas
论文部分内容阅读
Citalopram,chemically 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroiso-benzofuran-5-carbonitrile,is a serotonin reuptake inhibitor(SSRI).The pharmacological activity lies predominantly in its(S)-enantiomer,while the(R)-enantiomer is approximately 30-fold less potent.This study presents the optical resolution of citalopram enantiomers by a three-section simulated moving bed(SMB)with open-loop design.The separation condition was first investigated with a single column chromatography.The optimized chromatographic system,usingCHIRALCEL OZ(20μm)as stationary phase and isopropanol/hexane 15/85(v/v)as mobile phase,exhibits a good separation of citalopram enantiomers.An eight-column SMB system was subsequently employed to separate the enantiomers of citalopram.It is found that the purity of S-enantiomer collected from the extract of the SMB was up to 93.7%and the purity of R-enantiomer collected from the raffinate of the SMB was up to 97.0%,as the switching time was set to 6 min.This study demonstrates that the SMB is suitable for the separation of citalopram enantiomer.
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