【摘 要】
：
Background: Increased oxidative stress and vascular inflammation have been demonstrated in patients with cardiac syndrome X (CSX).Bilirubin, once considered simply the metabolic end product of heme de
【机 构】
：
National Yang-Ming University School of Medicine Taiwan
论文部分内容阅读
Background: Increased oxidative stress and vascular inflammation have been demonstrated in patients with cardiac syndrome X (CSX).Bilirubin, once considered simply the metabolic end product of heme degradation, has emerged as a potential endogenous inhibitor of atherosclerosis.Objective: This study was conducted to evaluate the prognostic role of serum bilirubin in disease progression and clinical outcome in patients with CSX.Methods: A total of 108 consecutive CSX patients were enrolled.Serum bilirubin levels were examined from blood samples collected before coronary angiography.All patients were prospectively followed up for 5 years.The primary end point was the combined occurrence of major adverse cardiovascular events (MACE) including cardiovascular and noncardiac death, nonfatal myocardial infarction (MI), nonfatal ischemic stroke, rehospitalization for unstable angina, and coronary revascularization.Results: There were 20 MACEs including 5 ischemic stroke, 5 noncardiac death, and 10 rehospitalization for unstable angina during follow-up.Patients with MACE had lower baseline serum bilirubin levels (P<0.001).All patients were stratified into the high-, normal-, and low-bilirubin group.The patients in high-bilirubin group had the lowest incidence of MACE (P=0.008).In a multivariate Cox regression analysis, serum bilirubin, in addition to age and basal superoxide generation of circulating mononuclear cells, was also an independent predictor of MACE (HR, 0.002; 95% CI, 0.000 to 0.520; P=0.028).Conclusions: In patients with CSX, baseline serum bilirubin level was associated with long-term outcomes.Serum bilirubin could be a predictive and protective biomarker for disease progression and the development of cardiovascular events in CSX patients.
其他文献
The Mitral valve is most commonly affected by Chronic rheumatic heart disease.Acquired mitral stenosis is usually a result of rheumatic heart disease.Pure mitral regurgitation may be rheumatic in orig
Cardiac surgery can relieve symptoms and improve the prognosis of patients with aortic stenosis.However, surgeryrelated morbidity and mortality are high when severe cardiac or extra-cardiac factors co
Preeclarnpsia is a potentially fatal hypertensive disorder specific to pregnancy with genetic, pathogenic, and symptomatic similarity to cardiovascular disease.Preeclampsia currently cannot be diagnos
Inferior platelet inhibition post percutaneous coronary intervention (PCI) is related to higher cardiovascular events.However, by doubling olopidogrel doses in patients with inferior platelet response
Western diet is closely associated with raising the incidence of insulin resistance-induced cardiovascular disease.The pathogenesis of obesity-induced cardiomyopathy is well established; however, the
Background: Wilkins score evaluates leaflet quality by its thickness, mobility, calcification, and the extent of subvalvular disease.A score of-3d8 has an excellent immediate and long term result, whe
Synurus deltoides (Compositae) is an edible plant and largely distributed in North-East Asia.It has long been used as a folk medicine for treating inflammatory oedema, bleeding, vomiting and urinary i
Objectives: Patients (pts) with bicuspid aortic valves (BAV)are at higher risk for aorta-related death (rupture or dissection) than their peers with a tricuspid valve (TAV).Yet it is unclear if BAVs p
Purpose: Brain protection during aortic arch surgery is important, especially in patients with cerebral ischemia.To prolong the safe limits of conventional retrograde cerebral perfusion (RCP), Kitahor
Q-fever is a zoonosis caused by the Gram-negative bacterium Coxiella burnetii.Following primary infection, which is often asymptomatic, 1-5% of patients develop chronic Q-fever.C.burnetii endocarditis