The fabrication of hollow mesoporous materials with hierarchical pore structures,regular shape,and uniform particle size via a simple and efficient approach is a major challenge.In this study,a facile preparation approach of hierarchically structured double-shelled hollow mesoporous silica nanospheres(HS-DS-HMSN)has been developed.Treatment of monodisperse nonporous silica spheres with CTAB and F127 as well as N,Ndimethylhexadecylamine as a co-surfactant under basic conditions gives access to HS-DS-HMSNs of uniform particle size(162-364 nm).Such HS-DS-HMSN-type materials show high monodispersibility in aqueous solution,a doubleshelled structure with hierarchically adjustable pore sizes,perpendicularly aligned mesochannels,and high surface areas as well as large pore volumes.On the basis of structure and morphology evolutions as well as unambiguous and reproducible experimental data,a micelle-assisted self-assembly process is proposed as a mechanism of formation,further involving co-surfactant-expanded micelles and a heterogeneous nucleation deposition.The syntheses of a series of HS-DS-HMSNs with distinct particle sizes(162-364 nm)as well as distinct inner(range of thickness/pore size: 18-41 nm/3.1-3.7 nm)and outer shells(18-41 nm/3.7-8.0 nm)verify the feasibility and effectiveness of this approach.Such HS-DS-HMSNs show an ultrahigh adsorption rate(ca.1.7 mg mg-1 min-1)and loading(ca.300 mg g-1)for myoglobin(MB).