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昆虫来源的β-N-乙酰己糖胺酶参与昆虫生长发育的多个生理过程,如昆虫来源的Hex1酶能够专一水解以β-(1,4)糖苷键连接的几丁质寡糖底物,其主要在昆虫蜕皮时期的表皮中表达,RNA 干扰该基因能够导致昆虫在发育过程中不能正常蜕皮而死亡[1]。
OfHex1靶向糖基杂环硫苷抑制剂分子的设计与活性研究
【摘 要】
：
昆虫来源的β-N-乙酰己糖胺酶参与昆虫生长发育的多个生理过程,如昆虫来源的Hex1酶能够专一水解以β-(1,4)糖苷键连接的几丁质寡糖底物,其主要在昆虫蜕皮时期的表皮中表达,RNA 干扰该基因能够导致昆虫在发育过程中不能正常蜕皮而死亡[1]。
【机 构】
：
中国农业大学,理学院,应化系,北京 100193 大连理工大学,生命科学与技术学院,大连 1160
【出 处】
：
中国化学会第十届全国化学生物学学术会议
【发表日期】
：
2017年10期
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