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The framework for today: Surgery, and Care of the patient· Successful Experimental surgery: · How to produce controlled, repeatable experimental models · How to optimise animal welfare Aseptic technique Care of the animal before, during, after surgery Analgesia Aims of experimental surgery to create a defined, reproducible animal model with minimal variability· Requires attention to detail in technique · Prevent any confounding features through: Competence in technique·Familiarity with local anatomy · Prevent infection · Prevent pain · Speed recovery to normal