【摘 要】
：
All organisms contain thousands of proteins and peptides in their body fluids.A deeper insight into the distribution and the functional relevance of these polypeptides under different physiological an
【机 构】
：
Medical School of Hannover;Mosaiques Diagnostics and Therapeutics AG Germany
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
All organisms contain thousands of proteins and peptides in their body fluids.A deeper insight into the distribution and the functional relevance of these polypeptides under different physiological and pathophysiological conditions and the resulting discovery of specific biomarkers would greatly enhance both diagnosis and therapy of specific diseases.We have developed and evaluated a proteome-analysis based approach for clinical applications,such as disease diagnosis and assessment of response to therapy.The stable,robust and reproducible technology,consisting of capillary electrophoresis coupled to time-of-flight mass spectrometers (CE-TOF-MS) and software solutions necessary to evaluate the vast amount of information enable highly reproducible analysis of 1000-5000 polypeptides in one sample within 45-60 min,hence is applicable as routine clinical procedure.
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