【摘 要】
：
Cytochrome P450 (CYP) epoxygenases, such as those from the CYP2C and CYP2J subfamilies, catalyze oxidation of arachidonic acid to four regioisomeric epoxyeicosa
【机 构】
：
LaboratoryofRespiratoryBiology,NationalInstituteforEnvironmentalHealthSciences,NationalInstitutesofH
【出 处】
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2014 International Symposium on Polyunsaturated Fatty Acids
论文部分内容阅读
Cytochrome P450 (CYP) epoxygenases, such as those from the CYP2C and CYP2J subfamilies, catalyze oxidation of arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (5,6-, 8,9-, 11,12-, and 14,15-EET).EETs induce vasodilation by activating vascular smooth muscle large-conductance, Ca2+-activated K+ channels, are anti-inflammatory in endothelial cells through inhibition of NF-kB, and preserve mitochondria in cardiomyocytes after cardiac ischemia and reperfusion (I/R).
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