Recombinant heat shock protein 60 stimulates the migration of vascular smooth muscle cells via the T

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：roc59516663

【摘要】

：

Atherosclerosis is a multifactorial disease for which a number of different pathogenicmechanisms have been proposed.Growing evidence indicates that heat shock protein(HSP) 60 has a strong association

【作者】

：

赵莹魏旭格李培张晨旭崔颖秦元华金敏丽高颖

【机构】

：

大连医科大学

【出处】

：

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

HSP60 migration ERK TLR4 VSMC

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Atherosclerosis is a multifactorial disease for which a number of different pathogenicmechanisms have been proposed.Growing evidence indicates that heat shock protein(HSP) 60 has a strong association with atherosclerosis.However, the precise mechanism(s)by which HSP60 promotes atherosclerosis remains unclear.In the present study, we foundthat the HSP60 mRNA and protein expression levels in thoracic aortas significantly increasedin high-fat diet (H.F.D.) and in atherosclerosis (AS) mice.

其他文献

Lower level of let-7c in the serum of human breast cancer

[Purpose] Circulating microRNAs (miRNAs) are important in diagnosis of diseases for thereason that miRNAs in serum or plasma are more stable.This study aims to explore the relationshipbetween the leve

会议

Circulating miRNA breast cancer let-7c predictive factor ROC analysis

Chinese herbs attenuates myocardial damage of heart failure inrats through different subtypes of NOX

Aim:To investigate the myocardial injury effects of different subtypesof NADPH oxidase ona rat heart failure (HF) model,and the therapeutic effects of Qishenyiqi (QSYQ), a commonlyroutine treatment dr

会议

Chinese herbs heart failure

Compound TI503 Inhibits Breast Cancer Cells Proliferation throughUp-regulating the Expression of TSP

Testes-specific protease 50(TSP50), an oncogene is expressed abnormally at high levels inmost cancer tissues and low levels in normal tissues.Down-regulation of TSPS0 expressionhas been found to reduc

会议

compound TI503 miR-937-5p miR-4709-3p TSP50 breast cancer

Inhibitive effect of dexamethasone loaded layered doublehydroxide on Th2 cell development in a rat a

Although inhaled steroids are the treatment of first choice to control asthma, frequentcorticosteroid steroid administration is associated with many side effects such as adrenocorticalsuppression, Cus

会议

airway hyperresponsiveness Dexamethasone Sodium Phosphate solid lipidn anopartic

20(S)-protopanaxadiol activates ATF4 to induce cell apoptosis inhuman umbilical vein endothelial cel

20(S)-Protopanaxadiol (PPD) type ginsenoside is generally believed to be one of the mostpharmacologically active components of panax ginseng.Upon oral consumption, the20(S)-protopanaxadiol ginsenoside

会议

protopanaxadiol apoptosis PERK ATF4 HUVECs

Enhanced anti-inflammatory potential of encapsulated solid lipidnanoparticles of curcumin: a natural

Curcumin (Cur) is a naturally derived, novel anti-inflammatory agent, but its poor syringeabilitylimits its clinical use.The aim of the present study is to encapsulate Cur into solidlipid nanoparticle

会议

Curcumin Solid Lipid Nanoparticles (SLNs) Cellular Uptake Sustained ReleaseA nti

Selection of small molecules targeting Dclk1 of tumor stem cellsby phage display and computer aided

Targeted therapy is a promising way for cancer based drug development.Among variouscancer associated targets, tumor stem cells (TSCs) hold great potential as recent discoveryof their important role in

会议

Dclk1 peptide inhibitors virtual screening bioinformatic phage display

Generation of orphan GPCR libraries for screening protein/peptideligands

G protein-coupled receptors (GPCRs) are the largest group of the cell membrane receptorsplaying critical biological functions.Human genome encodes approximately 400 nonolfactoryGPCRs.So far, the endog

会议

Explore Inhibition mechanism of potential inhibitors forThioredoxin Glutathione Reductase by Molecul

Schistosomiasis is the second most socioeconomically devastating parasitic disease, (aftermalaria) in the world.The current chemotherapy mainly relies on praziquantel.However, Schistosoma displaying l

会议

TGR Molecular docking Inhibition mechanism Schistosomiasis

Targeted disruption of □-arrestin 2-mediated signaling pathwaysby aptamer chimeras leads to inhibiti

β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerouscritical cellular pathways, are attractive therapeutic targets because they promotetumorigenesis in sev

会议

arrestin leukemia

Recombinant heat shock protein 60 stimulates the migration of vascular smooth muscle cells via the T

与本文相关的学术论文