【摘 要】
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Alzheimer’s disease (AD) is the major neurodegenerative disease affecting the elderly.Unfortunately,no effective therapeutic method is available.The accumulati
【机 构】
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SchooloflifeSciences,TsinghuaUniversity,Beijing100084,China
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Alzheimer’s disease (AD) is the major neurodegenerative disease affecting the elderly.Unfortunately,no effective therapeutic method is available.The accumulation of amyloid-β (Aβ) peptides,which forms the major component of senile plaques (SP) in patient brains,is hypothesized to be the primary causative event in AD pathogenesis.Considerable In vitro evidence indicates that the aggregation oligomerization of Aβ is promoted in the presence of Zn; however,the functional role of Zn in AD pathogenesis is still not well clarified in vivo.Based on the knowledge above,we investigated the effect of modulation of ZIP expression on the AD pathological process in a genetically tractable model,Drosophila melanogaster.
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