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5. Pharmacological targeting of p21-activated kinase-4 overcomes tamoxifen-resistance in breast cancer

Pharmacological targeting of p21-activated kinase-4 overcomes tamoxifen-resistance in breast cancer

来源 :第四届广州国际肿瘤学会议 | 被引量 : 0次 | 上传用户：xiaoming198877

【摘 要】

：

　　Tamoxifenresistance leads to lethality in a substantial fraction of estrogen positivebreast cancer patients.Here,we show that high p21-activated kinase-4(PA

【作 者】

：

Jian Zhu Ting Zhuang Zhilun Li Staffan Str(o)mblad Julie Lorent Karin Dahlman-Wright 

【机 构】

：

Department of Biosciences and Nutrition,Karolinska Institutet,S-14183 Huddinge,Stockholm,Sweden

【出 处】

：

第四届广州国际肿瘤学会议

【发表日期】

：

2015年期

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　　Tamoxifenresistance leads to lethality in a substantial fraction of estrogen positivebreast cancer patients.Here,we show that high p21-activated kinase-4(PAK4)expression was linked to poor patient outcome in tamoxifen-treated breast cancer patients.

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