【摘 要】
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We report a potent antitumor effect of berberine, an isoquinoline alkaloid, on GBM.Berberine was found to have an IC50 that is much lower than temozolomide in vitro in U87, U251 and U118 glioblastoma
【机 构】
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Shandong University
【出 处】
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2014全球华人遗传学大会暨全国第十三次医学遗传学学术会议
论文部分内容阅读
We report a potent antitumor effect of berberine, an isoquinoline alkaloid, on GBM.Berberine was found to have an IC50 that is much lower than temozolomide in vitro in U87, U251 and U118 glioblastoma cells.we observed that the antitumor effect of berberine on glioblastoma cells was primarily achieved through induction of cellular senescence.In glioblastoma cells treated with berberine, the level of epidermal growth factor receptor (EGFR) was greatly reduced.Examination of the activities of the kinases downstream of EGFR revealed that the RAF-MEK-ERK signaling pathway was remarkably inhibited.Furthermore, the cellular senescence induced by berberine could be rescued by introduction of a constitutive active MKK.Berberine also potently inhibited the growth of tumor xenografts, which was accompanied by downregulation of EGFR and induction of senescence.Our findings thus revealed a new route by which berberine exerts its anticancer activity.
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